Objective:To explore the areas of abnormal brain activity in patients with irritable bowel syndrome(IBS)using resting state functional magnetic resonance imaging(rs-fMRI),revealing underlying neural mechanisms in patients with IBS.Methods:The literature before March 2023 were searched,which discussed the abnormal brain activity changes on resting state in patients with IBS u-sing amplitude of low-frequency fluctuation(ALFF),fraction amplitude of low-frequency fluctuation(fALFF)and regional homogeneity(ReHo)methods.The brain regions with abnormal local spontane-ous brain activity in IBS patients compared with healthy volunteers in previous studies were summa-rized,and the data were analyzed by signed differential mapping(SDM)software.Results:A total of 16 studies were included(461 cases of IBS and 416 healthy controls).Based on the meta-analysis,the local spontaneous brain activity of left lingual gyrus,left cuneus,right insular,right middle occipital gyrus and right thalamus significantly increased in IBS patients.However,the local spontaneous brain activi-ty significantly decreased in the right ilerectus muscle,right middle frontal gyrus and right superior marginal gyrus(P＜0.001,peak height Z＞1,cluster range ≥20 voxel).Conclusion:A meta-analysis was used to identify brain regions with associated abnormal core brain function in IBS patients.These findings help delineate specific areas of interest and understand the neurobiological basis of IBS.
关键词
肠易激综合征/局部一致性/低频波动幅度/分数低频波动幅度/磁共振成像/元分析/标记差异映射分析
Key words
Irritable bowel syndrome/Regional homogeneity/Amplitude of low-frequency fluctuation/Fraction amplitude of low-frequency fluctuation/Magnetic resonance imaging/Meta-anal-ysis/Signed differential mapping
维普
万方数据