Objective:To evaluate the diagnostic efficacy of 3.0T free-breathing non-contrast-en-hanced whole-heart coronary artery MR imaging in significant vascular stenosis based on coronary ar-tery segment levels.Methods:From May 2021 to June 2023,98 patients scheduled for coronary angiog-raphy(CAG)at the First Affiliated Hospital of Henan University of Traditional Chinese Medicine were enrolled consecutively.All patients underwent 3.0T non-contrast-enhanced MR coronary angiog-raphy(CMRA)one week before CAG.Following both examinations,the ability of CMRA to detect significant coronary artery stenosis(lumen diameter reduction ≥50%)was evaluated at the vascular segment level,using CAG as the"gold standard".Results:The diagnostic efficacy of CMRA at the vas-cular segment level for significant vascular stenosis showed a sensitivity of 75.42%,specificity of 96.50%,positive predictive value of 82.41%,negative predictive value of 94.76%,and accuracy of 92.74%;Except for the LCX2 segment,the area under the ROC curve(AUC)for the LM,LAD1,LAD2,LAD3,LCX1,RCA1,RCA2,and RCA3 segments was greater than 0.75.The diagnostic results for the LAD3 and LCX2 segments were greatly affected by the image quality.Conclusion:3.0T non-contrast-enhanced MR coronary imaging is a promising non-invasive and radiation-free coronary ima-ging technique with diagnostic efficacy comparable to CAG,which can detect significant coronary ar-tery stenosis in patients with suspected coronary artery disease.