Correlation analysis of quantitative parameters for contrast-enhanced ultrasound and dynamic enhanced MRI with histological grading,lymph node metastasis,LOXL2 and PTK6 expression in breast cancer
Objective:To investigate the correlation of contrast-enhanced ultrasound and dynamic enhanced MRI parameters with clinicopathological features and prognostic factors of breast cancer.Methods:From January 2020 to June 2023,97 breast cancer patients who underwent surgical treatment in our hospital were included.Contrast-enhanced ultrasound was performed using the Mindray Resona 7 color ultrasonic diagnostic instrument,recording time to peak(TTP),peak intensity(PI),and area under the curve(AUC).Dynamic enhanced MRI was conducted using the GE SIGNA Pioneer 3.0T MR Scanner,recording volume transfer constant(Ktrans),rate constant(Kep),and extravascular extra-cellular space volume ratio(Ve).The expression levels of LOXL2 and PTK6 in breast cancer tissues were detected by immunohistochemistry.Results:TTP and Ve were significantly higher in grades Ⅰ～Ⅱ than in grade Ⅲ,while PI,Ktrans,and K ep were significantly lower in grades Ⅰ～Ⅱ compared to grade Ⅲ(P＜0.05).TTP of patients without lymph node metastasis was significantly higher than that of patients with lymph node metastasis,while PI,Ktrns,and Kep were significantly lower than those with lymph node metastasis(P＜0.05).Patients with low expression of LOXL2 had significantly high-er TTP and significantly lower Ktrans and Kep than those with high expression(P＜0.05).Similarly,pa-tients with low expression of PTK6 had significantly higher TTP and significantly lower PI,Ktrans,and Kep than those with high expression(P＜0.05).Multivariate logistic regression analysis indicated that lower TTP,Ve,and higher PI,Ktrans,and Kep were independent factors for grade Ⅲ histology(P＜0.05).Lower TTP and higher PI and Kep were independent factors for lymph node metastasis(P＜0.05).Lower TTP and higher Kep were independent factors affecting the high expression of LOXL2(P＜0.05).Lower TTP and higher PI and Kep were independent factors factors for high expression of PTK6 expression(P＜0.05).ROC curve analysis results showed that the AUC for evaluating histolog-ical grade,lymph node metastasis,LOXL2 expression,and PTK6 expression,using contrast-enhanced ultrasound combined with dynamic contrast-enhanced MRI parameters,were 0.962(95％CI=0.929～0.994),0.812(95％CI=0.727～0.897),0.788(95％CI=0.698～0756),respectively.Conclusion:The parameters of contrast-enhanced ultrasound and dynamic enhanced MRI are related to the clinicopath-ological features and prognostic factors of breast cancer and have good value in evaluating the histolog-ical grade of patients.
Breast cancerUltrasonographyMagnetic resonance imagingClinical stageLymph node metastasisPrognostic factor
万方数据
维普
