Objective:To investigate a novel diagnostic strategy for the high-risk population of hepatocellular carcinoma(HCC)using abbreviated gadoxetic acid disodium(Gd-EOB-DTPA)-en-hanced MRI(AMRI).Methods:The clinical and imaging data of 405 patients from January 2020 to June 2023 with chronic hepatitis B or C and/or liver cirrhosis were retrospectively analyzed,and all pa-tients underwent Gd-EOB-DTPA dynamic enhanced MRI.The complete Gd-EOB-DTPA-enhanced MRI,including T1WI,T2WI,four dynamic contrast-enhanced phases,diffusion-weighted imaging(DWI)and hepatobiliary phase(HBP),and 2 sets of AMRI extracted from the full sequences,inclu-ding non-contrast(NC)-AMRI set(T2WI+DWI)and HBP-AMRI(T2 WI+DWI+HBP)were re-viewed by two abdominal MRI diagnostic doctors.The diagnosis of positive HCC was based on patho-logical and follow-up findings.Cochran s Q test was used to compare the sensitivity,specificity,and ac-curacy of three sets and receiver operating characteristic(ROC)curves was depicted,and the area un-der the ROC curves(AUC)was compared.Results:Among the 227 included patients(137 HCC-posi-tive and 90 HCC-negative),a total of 238 lesions were detected.The diagnostic results obtained by the three scanning protocols were almost completely consistent(K＞0.80)by both physicians.The sensi-tivity of the full Gd-EOB-DTPA-enhanced MRI,NC-AMRI,and HBP-AMRI were 95.17％,82.76％,and 94.48％;the specificity was 96.77％,86.02％,and 91.39％;and the accuracy were 95.79％,84.03％,and 93.28％,respectively.The sensitivity(Cochran's Q=34.111,P＜0.001),specificity(Coch-ran's Q=11.200,P=0.004),and accuracy(Cochran's Q=37.152,P＜0.001)among 3 sets were statis-tically significant.When every two sets were compared,the highest specificity was found in the full Gd-EOB-DTPA-enhanced MRI,but sensitivity and accuracy were not statistically different between the full Gd-EOB-DTPA-enhanced MRI and HBP-AMRI,and the lowest sensitivity and accuracy was found in the NC-AMRI.The AUCs of three sets in descending order were full Gd-EOB-DTPA-en-hanced MRI(0.960),HBP-AMRI(0.913),and NC-AMRI(0.844),and the difference between every two sets was statistically significant after DeLong's test(P＜0.05).Conclusion:Both AMRI sets could be used as a new diagnostic strategy for high-risk population of HCC,especially for patients who can-not tolerate prolonged examinations,and HBP-AMRI is considered to be the optimal abbreviated se-quence protocol for Gd-EOB-DTPA contrast-enhanced MRI.
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