Value analysis of amide-proton transfer imaging combined with prognostic nutritional index in predicting the efficacy of neoadjuvant chemoradiotherapy for locally advanced rectal cancer
Objective:To investigate the value of quantitative parameters of amide-proton trans-fer imaging(APT)including APT signal intensity(APT SI)and apparent diffusion coefficient(ADC)combined with prognostic nutrition index(PNI)in predicting the efficacy of neoadjuvant chemoradio-therapy(NCRT)for locally advanced rectal cancer.Methods:A total of 98 patients with locally ad-vanced rectal cancer who received complete NCRT and surgical treatment were selected as the study objects.All the patients underwent APT examination before NCRT,and the APT SI and ADC values were determined,and the PNI was calculated and recorded.All subjects were treated with NCRT and divided into pathological complete response(PCR)group and non-PCR group according to postopera-tive pathological results.Results:After NCRT treatment,40 cases(40.82％)of 98 patients with rectal cancer achieved PCR,and 58 cases(59.18％)did not achieve PCR.There was significant difference in maximum tumor diameter between the two groups(P＜0.05).The APT SI and PNI before treatment in PCR patients were significantly higher than those in non-PCR patients,and the ADC before treat-ment was significantly lower than that in non-PCR patients,with statistical significance(P＜0.05).There was a significant negative correlation between APT SI and ADC before treatment in rectal canc-er patients(r=-0.366,P=0.046).Univariate logistic regression analysis showed that APT SI,ADC and PNI were closely related to non-PCR after NCRT in rectal cancer patients(P＜0.05).The ROC curve analysis results showed that the sensitivity and specificity of APT SI,ADC and PNI alone and the combined were 75.9％and 52.5％,69.0％and 67.5％,56.9％and 72.5％,82.8％and 82.5％,re-spectively.Conclusion:The combination of APT quantitative parameters and PNI helps to predict the efficacy of NCRT in patients with locally advanced rectal cancer.
Amide proton transfer imagingRectal cancerNeoadjuvant chemoradiotherapyCurative effectApparent diffusion coefficientPrognostic nutritional index
维普
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