Objective:To analyze the difference of SN subregions quantitative susceptibility value(QSV)and the value in the diagnosis of Parkinson's disease(PD)based on quantitative susceptibility mapping(QSM).Methods:36 PD patients(PD group)and 22 healthy control group(HC group)diag-nosed in our hospital from September 2021 to March 2024 were included.All subjects underwent MR and QSM scans.QSM and true SWI(tSWI)were obtained after post-processing.In the QSM,SN was divided into four subregions:rostral anterior-SN(aSNr),rostral posterior-SN(pSNr),caudal anterior-SN(aSNc),caudal posterior-SN(pSNc),and the QSV were recorded.The swallow-tail sign was ob-served and scored(0～1)on the tSWI.The inter-group differences of QSV of SN subregions between the two groups were compared.The intra-group differences of QSV of rostral SN and caudal SN were compared.Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficiency of SN subregions QSV and swallow-tail sign score independently and in combination.Spearman corre-lation analysis was used to analyze the correlation between QSV and PD disease duration and swallow-tail sign score.Results:Compared with HC group,the QSV of SN,rostral SN(aSNr and pSNr)and caudal SN(aSNc and pSNc)in PD group were increased(P＜0.05).The QSV of caudal SN was higher than rostral SN in PD group and HC group(P＜0.05).ROC analysis showed that AUC(95％CI),sen-sitivity and specificity of combined application of the QSV of pSNc and the swallow-tail sign score in diagnosing PD were 0.941(0.882～1.000),94.4％and 86.4％,respectively.The AUC was significantly higher than that of single application of the QSV of pSNc(AUC=0.833)and the swallow-tail sign score(AUC=0.876),and the difference was statistically significant(P＜0.05).The QSV of caudal SN and pSNc were positively correlated with the course of disease(r=0.345,P＜0.05;r=0.358,P＜0.05)and swallow tail sign score(r=0.379,P＜0.05;r=0.411,P＜0.05).Conclusion:There are differences in QSV values of SN sub-regions between PD patients and healthy subjects.The QSV of caudal SN is higher in PD group and is correlated with the course of disease to some extent.The com-bined application of the QSV of pSNc and the swallow-tail sign score is more valuable in the diagnosis of PD.
万方数据
维普
