Objective:The purpose of this study was to investigate the clinical features and chest CT findings of Chlamydia psittaci pneumonia confirmed by metagenomic next-generation sequencing(mNGS).Methods:The clinical data and chest CT findings(the first CT and follow-up CT within one month)of 48 patients in our hospital with Chlamydia psittaci pneumonia confirmed by mNGS between August 2020 and October 2023 were retrospectively analyzed.Results:Among the 48 patients,40 cases(83.3％)had an exposure history to poultry.All cases had fever.White blood cells were elevated in 12 cases(25.0％),proportion of neutrophils was elevated in 33 cases(68.8％),and C-reactive protein was elevated in 42 cases(87.5％),with C-reactive protein＞100mg/L in 29 cases(60.4％).The first chest CT scan showed that the lesion was located in the lower lobe in 41 cases,single lobe involvement in 35 cases(72.9％),all the lesions were peripheral distribution or along the bronchovascular bundle,the most common finding was consolidation(97.9％,47/48)with air bronchogram(97.9％,46/47)and halo sign(74.5％,35/47),crazy-paving appearance in 18 cases(37.5％),ipsilateral pleural effusion in 18 cases(37.5％).After adjustment of antibiotic treatment,the follow-up CT of 45 cases showed im-proved in 30 cases(66.7％),fibrous lesions in 10 cases(22.2％).The halo sign and crazy-paving ap-pearance were absorbed in 18 cases(40.0％)and 14 cases(31.1％)on the follow-up CT images.Con-clusion:The chest CT manifestations of Chlamydia psittaci pneumonia are mostly showed as consolida-tion in the lower lobes with air bronchogram sign and halo sign,often accompany with crazy-paving appearance and pleural effusion.
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