全身放疗(Total body irradiation,TBI)是对患者全身进行照射的一种特殊放疗技术,是血液系统疾病行造血干细胞移植前的一种预处理手段,其主要作用包括杀灭残存肿瘤细胞、抑制机体免疫应答、为造血干细胞移植排空骨髓空间等.目前,全身放疗实施的主要实现方式包括长距离固定野照射、容积旋转调强和分段照射.在本文中,我们结合自身临床实践经验,综述了上述这些实现方式的技术特点和相关研究进展.
Implementation modalities and research progress of total body irradiation
Total body irradiation(TBI)is a technique that irradiates the entire body of the patient.It serves as a conditioning regimen prior to hematopoietic stem cell transplantation for hematological diseases.Its primary functions include killing residual tumor cells,immunosuppression,and creating space in the bone marrow for hematopoietic stem cell transplantation.Currently,the main methods of implementing TBI include extended distance fixed field irradiation,volumetric modulated arc therapy(VMAT-TBI),and segmented irradiation.In this paper,based on our clinical experience,we review the technical characteristics and relevant research progress of these three methods.
Total body irradiationHematopoietic stem cell transplantationConditioning regimen
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