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电膜萃取技术提取生物检材中滥用药物的研究进展

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电膜萃取技术(EME)是一种绿色高效的新型样品前处理技术,因其选择性好、净化能力强等优点,近年来被广泛应用于食品分析、环境分析、药物分析以及法医毒物分析领域。该文总结了近五年EME在滥用药物提取中的研究进展,重点总结了EME从不同生物检材(如血液、尿液、唾液、毛发和组织等)中提取富集滥用药物的应用情况,特别关注了其对于毒品、新精神活性物质(NPS)以及临床类滥用药物的分离性能。同时,也探讨了EME应用于法医学领域面临的挑战,并展望了其未来的发展方向。
Advances in Electromembrane Extraction of Drugs-of-abuse from Biological Samples
Electromembrane extraction(EME)isa green and efficient microextraction technique,which has been widely applied in all kinds of fields including food analysis,environmental analysis and forensic toxicological analysis in recent years due to the advantages of high selectivity,sufficient sample clean-up capability,and simple in operation.This review summarized the research progress in EME for the separation of drugs-of-abuse over the past five years,with a particular emphasis on its application in extracting and enriching abused drugs from various biological matrices,and paid spe-cial attention to the separation performance of EME for illicit drugs,new psychoactive substances(NPS),and addictive pharmaceuticals.Furthermore,this review also examined the challenges faced by EME in its routine application within the field of forensic science and provided a prospective outlook on the future development directions of EME.

electromembrane extractionforensic toxicological analysissample preparationdrugs-of-abusehairsaliva

高同飞、董壮壮、沈先涛、黄垂秀

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华中科技大学 同济医学院 法医学系,湖北 武汉 430030

华中科技大学 同济医学院 公共卫生学院教育部环境与健康重点实验室,湖北 武汉 430030

电膜萃取 法医毒物分析 样品前处理 滥用药物 毛发 唾液

2025

分析测试学报
中国广州分析测试中心,中国分析测试协会

分析测试学报

北大核心
影响因子:1.498
ISSN:1004-4957
年,卷(期):2025.44(1)