Advances in Direct Analysis in Real Time Mass Spectrometry and Its Hyphenation with Sample Pretreatment Techniques
Direct analysis in real time mass spectrometry(DART-MS)is widely used in food analy-sis,forensic science,pharmaceutical analysis,clinical science,environmental science and other fields,as it requires no or minimal sample preparation and can perform in-situ ionization and direct sample analysis.Although the quantitative results of DART-MS have been reported to be comparable to those of liquid/gas chromatography-mass spectrometry,the detection performance of trace analytes is still an important issue.To obtain more accurate quantitative results,a series of sample pretreat-ment technologies have been developed to be combined with DART-MS.In this review,the general principle of DART-MS is introduced,followed by its applications in different research fields that do not require sample pretreatment.Sample pretreatment technologies coupling with DART-MS,in-cluding solid-phase extraction(SPE),solid-phase microextraction(SPME),solid-phase mesh en-hanced sorption from headspace(SPMESH),dispersive solid-phase extraction(DSPE),dispersive micro solid-phase extraction(DMSPE),mechanochemical extraction(MCE),microwave-assisted ex-traction(MAE)and thermal desorption(TD)are further summarized and commented.The possible optimizations in the future are also proposed in this review,hoping to provide great insight into the applications of direct sample analysis by DART-MS and the development of sample pretreatment tech-nologies coupling with DART-MS.
mass spectrometrydirect analysis in real timedirect sample analysissample pre-treatment technology
万方数据
维普
