Advances in the Application of Surface-imprinted Microspheres for Sample Pretreatment in Aqueous Media
Hydrogen bonding was usually the main mechanism for molecularly imprinted polymers to recognize template molecules.Due to the interference of many influencing factors such as water mole-cules,efficient identification of analytes in water environment has always been a major challenge for molecularly imprinted techniques.Surface-imprinted microspheres had the characteristics of large surface area and easy modification,which could be flexibly applied to meet the needs of various aque-ous sample pretreatments,which was one of the effective methods to overcome the difficulties of aque-ous phase identification.This paper reviewed various preparation strategies for aqueous-phase recog-nition of surface-imprinted microspheres and their representative applications in recent years,includ-ing surface-imprinted microspheres with different substrates,hydrophilic recognition,non-hydrogen-bonded synergistic recognition,and those based on special components.Various interfering factors and their regulatory strategies in the recognition of molecules in aqueous media were discussed in depth on the aspects of forces and recognition mechanisms.The application of surface-imprinted mi-crospheres in the pretreatment of aqueous samples was further presented.Finally,the challenges and future research trends of surface-imprinted microspheres in the field of aqueous sample pretreat-ment were discussed.
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