Research Progress on Mass Spectrometry Techniques Based on Chemical Derivatization for Lipid Analysis
Lipids are essential not only as major components of cell membranes but also in various bi-ological processes,such as energy storage and signal transduction.Due to its high sensitivity,accu-racy,and rapid analytical capabilities,mass spectrometry(MS)has become a core technology for lipid analysis,particularly in structural characterization.However,the structural diversity and high similarity of lipids present significant challenges for their qualitative and quantitative analysis using MS.Chemical derivatization techniques,by modifying lipid structures,can enhance ionization effi-ciency and improve the sensitivity and selectivity of MS detection,thus facilitating effective lipid structure identification and quantification.In recent years,the combination of chemical derivatiza-tion and MS has been widely applied in lipid analysis.This review summarizes the research progress of MS techniques based on chemical derivatization in resolving the structural characterization of lip-ids,improving detection sensitivity and quantitative accuracy,and coupling with advanced mass spectrometry over the last decade.
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