首页|MOFs和COFs在选择性富集及色谱分离中药活性成分中的应用进展

MOFs和COFs在选择性富集及色谱分离中药活性成分中的应用进展

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金属有机框架材料(MOFs)和共价有机框架材料(COFs)具有超大比表面积和可调节的孔径等结构特点,可以实现目标化合物的选择性富集和分离,在中药活性成分领域表现出广泛的应用前景。该文综述了MOFs、COFs的常用制备方法,阐述了 MOFs、COFs及其复合材料在选择性富集、色谱分离不同中药基质活性成分方面的应用,并结合网络药理学探讨了其在靶向中药活性成分方面的发展前景,为新型有机框架材料在中药有效成分领域的研究提供了思路。
Advances in the Application of MOFs and COFs for the Selective Enrichment and Chromatographic Separation of Active Ingredients in Traditional Chinese Medicine
Metal-organic frameworks(MOFs)and covalent organic frameworks(COFs)possess ex-ceptional attributes,notably their remarkably extensive specific surface areas and adjustable pore siz-es,which greatly facilitate the selective enrichment and separation of target compounds.These unique properties have exhibited considerable potential in the field of active components derived from traditional Chinese medicine(TCM).This review elucidates the prevalent methodologies for synthesiz-ing MOFs and COFs,and delves into their applications,alongside composite materials,in the se-lective enrichment and chromatographic separation of active ingredients from a diverse array of Chi-nese medicinal matrices.Moreover,it examines the future prospects of these materials in identifying active components of TCM through the perspective of network pharmacology,providing valuable in-sights for the exploration and development of novel organic framework materials within the domain of efficacious constituents in TCM.

metal-organic frameworkscovalent organic frameworksactive ingredients of TCMselective enrichmentchromatographic separation

司甜甜、赵薇、孙启慧、容蓉、孙敏

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山东中医药大学 药学院,山东 济南 250355

济南大学 化学与化工学院,山东 济南 250022

金属有机框架 共价有机框架 中药活性成分 选择性富集 色谱分离

2025

分析测试学报
中国广州分析测试中心,中国分析测试协会

分析测试学报

北大核心
影响因子:1.498
ISSN:1004-4957
年,卷(期):2025.44(1)