Progress in Microfluidic Paper-based Analytical Devices of Sample Pre-preparation Methods
Microfluidic paper-based analytical devices(μPADs)are straightforward,portable test-ing platforms based on paper materials that demonstrate significant potential for applications in do-mains such as clinical diagnosis,food quality control,and environmental monitoring.As a rapid de-tection platform,μPADs need to complete the sample pre-treatment process in addition to the rapid quantification of the target.In recent years,scientists have developed a variety of sample pre-treat-ment methods based on paper-based chips for the analysis of targets in different samples.Due to the strong compatibility of paper,enhancing the sample pre-treatment function of paper-based chips and linking them with various rapid detection methods can greatly expand the application areas of µPADs.This paper presents a summary of the sample pretreatment methods that including the paper-based chips with self-driving and the paper-based chips with external driving combined self-driving.It also outlines the research progress of paper-based chips in target analytes separation and enrich-ment,and discusses the advantages and limitations of various paper-based chips pre-treatment meth-ods.Furthermore,this paper looks at the direction of µPADs,which need to be developed commer-cially to meet the testing needs of various industries,in addition to continuously improving sample preprocessing capabilities to expand their application in sample preparation.
万方数据
维普
