Zr-based Metal-Organic Frameworks Selectively Targeted the Ac-tive Components of Alkaloids in Fishing Coptis chinensis Franch
Metal-organic frameworks(MOFs),owing to their readily modifiable structural features and distinctive molecular sieve effects,enable efficient enrichment of target compounds,thereby ex-hibiting vast potential applications in fields such as environmental science,food safety and medicinal health.In this study,MOF-808 was as carriers to achieve enrichment and extraction of alkaloid bio-active components from Coptis chinensis(Huanglian).Furthermore,we delved into the synergistic in-teractions during the extraction process of these alkaloids using MOFs in conjunction with low-co-sol-vent systems,based on their structural characteristics.By optimizing conditions such as incubation and extraction procedures,it achieved a remarkable recovery of 85.78％for jatrorrhizine from crude extracts of Huanglian.In addition,it boasted a wide linear range spanning from 0.1 to 300 μg·L-1,with ultra-low detection limits ranging from 0.02-0.05 μg·L-1 and relative standard deviations main-tained within 0.40％-4.7％.Additionally,for jatrorrhizine,epiberberine,coptisine,palmatine and berberine in the Huanglian crude extract matrix,the spiked recoveries reached an impressive range of 69.7％to 128％.This approach efficiently and rapidly enriches and extracts alkaloid bioac-tive components from the Huanglian,thereby offering a novel perspective for the research on the se-lective extraction and enrichment of active ingredients in traditional Chinese medicines using MOFs materials.
metal-organic frameworkselective enrichmentchromatographic separationactive ingredients of alkaloidsCoptis chinensis
万方数据
维普
