Coumarone-based fluorescent probe for biothiols detection
It is crucial to track the levels of biothiols in organisms for diagnosing and treating disorders associated with them.Coumarone derivatives as the fluorescent parent,the fluorescent probe JB for biothiolsdetection was synthesized using the straightforward procedure.Investigations into the fluorescence characteristics,anti-interference capacity,and live cell fluorescence imaging of the probe revealed that it had low basal fluorescence,strong specificity,low toxicity,high sensitivity,and good biocompatibility.It was also successfully applied for the fluorescence imaging of biothiols in T24 live cells.The probe is a promising tool for thedetection of small moleculebiothiol.
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