Detection of COVID-19 antibody by electrochemical sensor based on SPCE/rGO/AuNPs
In this paper,reduced graphene oxide/gold nanoparticles(rGO/AuNPs)composite was synthesized by in-situ growth method.Then,the rGO/AuNPs was characterized by scanning electron microscopy,X-ray diffraction pattern,X-ray photoelectron spectroscopy and ultraviolet-visible spectrometry.A simple electrochemical immunosensor for the detection of Corona virus disease 2019(COVID-19)antibody was constructed by using screen-printed carbon electrode(SPCE)as the based electrode and rGO/AuNPs as the electrode modification material and forming Au-S bond by self-assembly of AuNPs with antigen to immobilize the COVID-19 antigen.The results showed the COVID-19 antibody was detected in a linear range of 500 fg/mL-100 pg/mL,and the detection limit was 1.63 fg/mL.
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