Application of molecularly imprinted solid-phase extraction for the determina-tion of antibiotics residues in environment and food
The residues caused by excessive use of antibiotics pose a serious threat to the environment and human health.Its low contents,multiple types,and complexity of residual matrix usually require the combination of appropriate sample pretreatment techniques.Molecularly imprinted polymers(MIPs)have the characteristics of simple preparation,high selectivity,and low cost.They can recognize and enrich the targets in the samples through unique recognition sites,making them excellent adsorbents.Molecular imprinted solid-phase extraction(MISPE)technology using MIPs as adsorbents has been widely used in the pre-treatment of antibiotic samples.This article reviews the latest progress in samples pretreatment and chromatography analysis of antibiotics using MISPE from 2017.The preparation techniques and strategies of novel antibiotic MIPs,including nanoimprinting,surface imprinting,active controllable radical polymerization,dummy template imprinting,multi-functional monomer imprinting,and multi template imprinting were briefly introduced,and three modes of solid-phase extraction based on molecular imprinting,namely column packed solid-phase extraction(PSPE),dispersed solid-phase extraction(DSPE),and magnetic solid-phase extraction(MSPE),were briefly described.Subsequently,the applications of MISPE combined with chromatography in the analysis of antibiotic residues in the environment and food were reviewed.Finally,the challenges faced in the preparation and pre-treatment of antibiotic MIPs were prospected.This article aims to provide reference for the enrichment,purification,and detection of antibiotic drugs using MIPs combined with solid-phase extraction.
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