In order to further investigate the inhibitory effect of Deoxyelephantopin(DET)on H460 cell line of human cell lung cancer,this study employed network pharmacological analysis to identify potential signaling pathways of DET affecting hu-man cell lung cancer H460 cell line.Cell proliferation and apoptosis experiments were then conducted to examine the effects of different concentrations DET on proliferation and apoptosis of H460 cell line of human cell lung cancer.Network pharmacologi-cal analysis showed that DET may inhibit cell proliferation by affecting apoptosis-related proteins to induce apoptosis.The re-sults of MTT and apoptosis experiments showed that DET could effectively inhibit the proliferation of H460 cells and promote the apoptosis of H460 cells in a dose-dependent manner.
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