The effects of PI3K/Akt/mTOR,Wnt/-catenin,JAK/STAT signaling pathways and flavonoids on gastric cancer
Gastric cancer is a malignant tumor of epithelial origin of gastric mucosa,which often occurs with abnormal cell proliferation or metabolic signal pathway.Flavonoids are secondary metabolites of many plants.They belong to a diverse family of aromatic molecules with 2-phenylchromogen as the maternal core.They have anti-inflammatory,anti-oxidation,anti-tumor,immune regulation and other biological activities to multi-targets of the body's cells.Many studies have shown that it has signifi-cant curative effect on many common cancers,such as colon cancer,breast cancer,lung cancer,stomach cancer,etc.This article reviews the recent studies on the three target signaling pathways of gastric cancer:PI3K/Akt/mTOR,Wnt/β-catenin and JAK/STAT.The mechanism of these signal pathways and the effect of flavonoids on them are reviewed to provide reference for ex-ploring the prevention and treatment of gastric cancer by flavonoids.
gastric cancersignal pathwaymechanism of actionflavone
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