摘要
胃癌是胃黏膜上皮源性的恶性肿瘤疾病,往往伴随细胞增殖或代谢信号通路异常而发生.黄酮类化合物是多种植物的次级代谢物,属于 2-苯基色原酮为母核的多样化芳香类分子家族,具有对机体细胞多靶点抗炎、抗氧化、抗肿瘤及免疫调节等生物学活性,多项研究表明其对多种常见癌症如结肠癌、乳腺癌、肺癌和胃癌等有较为显著的治愈效果.本文综述了近年来有关胃癌靶点的三条信号通路PI3K/Akt/mTOR、Wnt/β-catenin和JAK/STAT的作用机制及黄酮类化合物对胃癌信号通路影响的研究成果,为探索黄酮类物质对胃癌的防治研究提供参考.
Abstract
Gastric cancer is a malignant tumor of epithelial origin of gastric mucosa,which often occurs with abnormal cell proliferation or metabolic signal pathway.Flavonoids are secondary metabolites of many plants.They belong to a diverse family of aromatic molecules with 2-phenylchromogen as the maternal core.They have anti-inflammatory,anti-oxidation,anti-tumor,immune regulation and other biological activities to multi-targets of the body's cells.Many studies have shown that it has signifi-cant curative effect on many common cancers,such as colon cancer,breast cancer,lung cancer,stomach cancer,etc.This article reviews the recent studies on the three target signaling pathways of gastric cancer:PI3K/Akt/mTOR,Wnt/β-catenin and JAK/STAT.The mechanism of these signal pathways and the effect of flavonoids on them are reviewed to provide reference for ex-ploring the prevention and treatment of gastric cancer by flavonoids.
基金项目
阜阳地方农产品食品工艺开发科研创新团队项目(FX2020KCT02)
NETL
NSTL
万方数据