首页|3种新精神活性物质的结构确证及未知毒品的定性鉴定

3种新精神活性物质的结构确证及未知毒品的定性鉴定

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目的 建立3种疑似新精神活性物质(new psychoactive substance,NPS)的结构确证方法,探索一种较为通用的定性检验方法.方法 利用红外吸收光谱、气相色谱-质谱(gas chromatography-mass spec-trometry,GC-MS)、核磁共振氢谱(1H-nuclear magnetic resonance spectroscopy,1H-NMR)、核磁共振碳谱(13C-nuclear magnetic resonance spectroscopy,13C-NMR)、核磁共振氟谱(19F-nuclear magnetic resonance spectroscopy,19F-NMR)等技术对公安机关送检的5份疑似含有NPS的检材进行成分鉴定及结构确证.结果 送检的5份检材中均检出NPS,共有3种于2024年7月1日被列管的NPS,分别为甲基胺酮(又称2-MDCK)、2-乙氨基-2-(2-氟苯基)环己酮(又称2-FXE)、1-[3,4-(亚甲二氧基)苯基]-2-二甲氨基-1-戊酮(又称dipentylone),前两者属于苯环己哌啶类NPS,第三种属于合成卡西酮类NPS.结论 本研究较为系统地介绍了3种NPS的红外吸收光谱、核磁共振波谱和质谱等表征手段的区分特征,可为未知毒品的定性鉴定提供参考.
Structure Confirmation of Three New Psychoactive Substances and Qualitative Identification of Unknown Substances
Objective To establish the structural confirmation methods of three suspected new psychoac-tive substances(NPSs),and explore a more general qualitative testing method.Methods Infrared ab-sorption spectroscopy(IR),gas chromatography-mass spectrometry(GC-MS),1H-nuclear magnetic reso-nance spectroscopy(1H-NMR),13C-nuclear magnetic resonance spectroscopy(13C-NMR),19F-nuclear magnetic resonance spectroscopy(19F-NMR)and other techniques were used to identify the composi-tion and structure of 5 samples containing suspected NPS submitted by public security bureaus.Results NPSs were found in the above 5 samples,and 3 were confirmed as NPS included in the newly listed controlled substances on July 1,2024,namely 2-(methylamino)-2-(2-methylphenyl)cyclohexan-1-one(2-MDCK),2-(ethylamino)-2-(2-fluorophenyl)cyclohexan-l-one(2-FXE),1-(3,4-methylenedioxy-phenyl)-2-(dimethylamino)pentan-1-one(dipentylone),respectively.The first two substances were phen-cyclidine NPS,and the third substance was synthetic cathinone NPS.Conclusion This study systemati-cally summarizes the distinguishing features of the infrared absorption spectrometry,nuclear magnetic resonance spectroscopy and mass spectrometry of three NPSs,which can provide a reference for the qualitative identification of unknown substances.

forensic medicinetoxicological analysisnew psychoactive substance(NPS)phencyclidinessynthetic cathinonesinfrared absorption spectrometrynuclear magnetic resonance(NMR)spectroscopygas chromatography-mass spectrometrystructural analysis

聂宗炀、胡伟、李玲玉、章青波、黄欣、李波

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江西求实司法鉴定中心,江西 南昌 330006

法医学 毒物分析 新精神活性物质 苯环己哌啶类 合成卡西酮类 红外吸收光谱法 核磁共振波谱法 气相色谱-质谱法 结构解析

2024

10.12116/j.issn.1004-5619.2023.330101

法医学杂志
司法部司法鉴定科学技术研究所

法医学杂志

CSTPCDCHSSCD北大核心
影响因子：0.32
ISSN：1004-5619
年,卷(期)：2024.40(4)