T淋巴细胞在胆道闭锁炎症和纤维化发生过程中调控机制的研究进展
Research progress on the regulatory mechanism of T lymphocytes during inflammation and fibrosis of biliary atresia
何峰 1刘卓1
作者信息
- 1. 首都儿科研究所 生化和免疫学研究室,北京 100020
- 折叠
摘要
胆道闭锁是以新生儿肝组织纤维化、汇管区炎症等为主要特征的疾病,围产期病毒感染被认为是致病因素之一,机体免疫调控异常在疾病进程中发挥主要作用.T淋巴细胞在免疫调控紊乱、过强的炎症反应以及自身抗体产生起着关键性的作用.本文对与胆道闭锁发病相关的T淋巴细胞亚群的种类和特点进行阐述.
Abstract
Biliary atresia is characterized by hepatic fibrosis and inflammation in portal area of newborns,infected by virus in the perinatal period was considered to be an important cause.The abnormal immune regulation plays an important role in the process of biliary atresia,T lymphocytes plays a key role in immune disorder,severe inflammation and production of autoantibody.This article reviewed the research progress of different subtypes of T lymphocyte and their characteristic in Biliary atresia.
关键词
胆道闭锁/T淋巴细胞/炎症/纤维化/调控机制Key words
Biliary atresia/T lymphocyte/Inflammation/Fibrosis/Regulatory mechanism引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据