目的 探讨臭氧水疗对儿童特应性皮炎的治疗效果及炎性因子改变情况.方法 选取2019年4月至2021年4月河北中西医结合儿童医院收治的100例儿童特应性皮炎患者,将其按照随机数字表法分为对照组(n=50)和观察组(n=50).其中对照组患儿给予地氯雷他定干混悬剂口服,地奈德乳膏外用,再给予霍霍巴油婴儿润肤乳,观察组患儿在对照组的基础上,加用臭氧水疗.比较两组患儿血清炎性因子白细胞介素(interleukin,IL)-17、IL-13 水平及湿疹面积严重程度(eczema area and severity index,EASI)评分,特应性皮炎积分指数(scoring atopic dermatitis index,SCORAD)、生活质量、临床疗效及安全性.统计学方法采用独立样本t检验、配对样本t检验和x2检验.结果 治疗后,观察组与对照组血清IL-17水平[(23.8±2.0)ng/L与(26.9±2.5)ng/L,t=6.847],IL-13 水平[(26.8±2.1)ng/L与(30.6±2.6)ng/L,t=8.040],SCORAD 评分[(23.0±1.5)分与(30.3±2.0)分,t=20.648],EASI 评分[(2.1±0.8)分与(3.8±0.9)分,t=9.983],儿童皮肤生活质量指数(children dermatology life quality index,CDLQI)评分[(6.1±1.4)分与(9.6±1.8)分,t=8.470],婴儿皮肤生活质量指数(infant's dermatology life quality index,IDQOL)评分[(6.8±1.3)分与(10.8±1.8)分,t=7.947]比较,观察组均低于对照组(P值均＜0.001).观察组与对照组治疗后血清IL-17水平、IL-13水平、SCORAD评分、EASI评分、CDLQI评分、IDQOL评分明显低于治疗前,差异均有统计学意义(P值均＜0.05).观察组治疗总有效率高于对照组[94.0％(47/50)与76.0％(38/50),x2=5.020,P=0.025)].结论 臭氧水疗用于儿童特应性皮炎可有效改善患儿临床症状及睡眠质量,减轻瘙痒及炎症反应,提高生活质量,安全有效.
Analysis of curative effect of ozone hydrotherapy in children with atopic dermatitis
Objective To explore therapeutic effect of ozone hydrotherapy in children with atopic dermatitis and the changes of inflammatory factors.Method A total of 100 children with atopic dermatitis in Hebei Integrated Traditional Chinese and Western Medicine Children's Hospital from April 2019 to April 2021 were selected and divided into control group(n=50)and observation group(n=50)according to the random number table method.Children in the control group were given desloratadine dry suspension orally,desonide cream for external use,and then given jojoba oil baby lotion children in the observation group were treated with ozone hydrotherapy on the basis of control group.The levels of serum inflammatory factors interleukin-17(IL-17),interleukin-13(IL-13),and eczema area and severity index(EASI)score,scoring atopic dermatitis index(SCORAD),quality of life,clinical efficacy and security were compared between the two groups.The statistical methods performed by Independent sample t-test,paired sample t-test,and x2-test.Result After treatment,serum IL-17 level[(23.8±2.0)ng/L vs(26.9±2.5)ng/L,t=6.847],IL-13 level[(26.8±2.1)ng/L vs(30.6±2.6)ng/L,t=8.040],SCORAD score[(23.0±1.5)points vs(30.3±2.0)points,t=20.648],EASI score[(2.1±0.8)points vs(3.8±0.9)points,t=9.983],the children's dermatology life quality index(CDLQI)score[(6.1±1.4)points vs(9.6±1.8)points,t=8.470],the infants'dermatology life quality index(IDQOL)scores[(6.8±1.3)points vs(10.8±1.8)points,t=7.947]were lower in observation group than those in control group(all P＜0.001).After treatment,serum IL-17 level,IL-13 level,SCORAD score,EASI score,CDLQI score and IDQOL score in observation group and control group were significantly lower than before treatment,with statistical significance(all P＜0.05).The effective rate of observation group was higher than that of control group[94.0％(47/50)vs 76.0％(38/50),x2=5.020,P=0.025).Conclusion Ozone hydrotherapy for children with atopic dermatitis can effectively improve the clinical symptoms and sleep quality of patients,reduce itching and inflammatory reactions,and improve the quality of life,which is safe and effective.
Atopic dermatitis in childrenOzone hydrotherapyItchingSleepCurative effect
万方数据
维普
