发育医学电子杂志2024,Vol.12Issue(4) :314-320.DOI:10.3969/j.issn.2095-5340.2024.04.012

精子DNA碎片检测在男性不育症患者临床评估和治疗中的研究进展

Research progress of sperm DNA fragmentation detection in clinical evaluation and treatment of male infertility

张耀东 郭舒筱 颜宏利
发育医学电子杂志2024,Vol.12Issue(4) :314-320.DOI:10.3969/j.issn.2095-5340.2024.04.012

精子DNA碎片检测在男性不育症患者临床评估和治疗中的研究进展

Research progress of sperm DNA fragmentation detection in clinical evaluation and treatment of male infertility

张耀东 1郭舒筱 1颜宏利2
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作者信息

  • 1. 海军第九七一医院 检验科,山东 青岛 266071
  • 2. 海军军医大学长海医院 生殖医学中心,上海 200433
  • 折叠

摘要

近年来,我国人口呈现出生率降低和老龄化进程加快的国情,改善和提高男性生育力问题引发社会关注.精子DNA碎片指数(DNA fragmentation index,DFI)作为一种新的精子质量评价标志物,目前广泛应用于临床不育症患者精液样本检测中.随着2023年《精子DNA碎片检测的临床专家共识》发布,为精子DFI应用于不育症患者临床评估和治疗提供了依据和标准.本文将对近年来国内外报道的精子DFI与辅助生殖技术(assisted reproductive technique,ART)治疗结局关系、精子DFI与精子参数一致性关系、精子DFI检测方法评价等研究进行综述.

Abstract

As the decreasing birth rate and accelerating aging process,the research on improving male reproductive ability has taken extensive attention in recently years.As a new marker for sperm quality evaluation,sperm DNA fragmentation index (DFI) has been increasingly used in semen samples detection of male infertility.With the publication of clinical expert consensus on sperm DNA fragmentation detection in 2023,it provides the basis and standard for sperm DFI to clinical evaluation and treatment of male infertility.This review briefly summarizes the research progress on the relationship between sperm DFI and assisted reproductive technique (ART) treatment outcome,the consistency between sperm DFI and sperm parameters,and the evaluation of clinical sperm DFI detection methods in recent years.

关键词

精子/DNA碎片/不育症/妊娠

Key words

Sperm/DNA fragmentation/Infertility/Pregnancy

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基金项目

青岛市医药卫生面上项目(2023-WJZD238)

出版年

2024
发育医学电子杂志
人民卫生出版社

发育医学电子杂志

CSTPCD
影响因子:0.212
ISSN:2095-5340
参考文献量11
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