Mendelian randomization analysis on the causal relationship between systemic lupus erythematosus and preeclampsia
Objective To investigate the causal relationship between systemic lupus erythematosus (SLE) and preeclampsia (PE).Method Utilizing the R package TwoSampleMR (0.6.4),single nucleotide polymorphism (SNP) significantly associated with SLE were screened from the IEU OpenGWAS database and used as instrumental variables.A dataset containing 7071163 SNP for SLE and another with 24165538 SNP for PE were obtained.Mendelian randomization (MR) analysis were conducted using inverse-variance weighting (IVW),MR-Egger regression,the weighted median estimator (WME),simple mode (SM),and weighted mode (WM).The causal relationship between SLE and PE was evaluated by calculating odds ratios (OR) and 95％ CI.Cochran's Q test for heterogeneity,MR-Egger horizontal pleiotropy test and leave-one-out analysis were performed to assess the stability and reliability of the data.Result A total of 42 SNP were included as instrumental variables.The IVW analysis suggested a causal relationship between SLE and the risk of PE (OR=1.038,95％ CI:1.003-1.073,P<0.05).Consistent results were also obtained from the MR-Egger regression analysis (OR=1.094,95％ CI:1.020-1.174,P<0.05).However,no causal relationship was found between SLE and PE in the WME,SM,and WM analysis.Cochran's Q test for heterogeneity and MR-Egger horizontal pleiotropy test indicated no heterogeneity or horizontal pleiotropy among the SNP.The leave-one-out analysis suggested that no single SNP had a significant impact on the overall results.Conclusion MR analysis suggests that SLE may increase the risk of developing PE.
Mendelian randomizationSystemic lupus erythematosusPreeclampsiaGenome-wide association studySingle nucleotide polymorphism
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维普
