铜催化有机硼试剂参与的自由基不对称C(sp3)—C(sp2)键构建反应
Copper-catalyzed asymmetric radical C(sp3)—C(sp2)bond formation with organoboron reagents
徐丹彤 1梁思谋 2杨昌江 2李忠良 2顾强帅 3刘霖 2刘心元1
作者信息
- 1. 南方科技大学化学系深圳市格拉布斯研究院,广东深圳 518055
- 2. 南方科技大学化学系深圳市格拉布斯研究院,广东深圳 518055;大湾区大学(筹)化学系东莞市数据科学与智能医学重点实验室,广东 东莞 523000
- 3. 南方科技大学前沿与交叉科学研究院,广东深圳 518055
- 折叠
摘要
有机硼试剂具有易于合成、稳定以及低毒的优势,被广泛地应用于C—C键的构建中.其中,铜催化有机硼试剂参与的 自 由基不对称(杂)芳基/烯基化反应是构建手性C(sp3)—C(sp2)键的重要方式之一,该类型反应成功的关键在于手性配体的合理设计,其与铜组成的手性协同催化体系既要保证反应的高效启动,还要实现高活性烷基自由基的立体控制.本文综述了两种类型手性配体的发展对这个领域研究进展的影响,并对该领域做出展望.
Abstract
Organoboron reagents are widely applied in the C—C bond formation due to the advantages of easy synthesis,stability,and low toxicity.Among them,copper-catalyzed asymmetric radical(hetero)ar-yl/alkenylation of organoboron reagents is an important approach to efficiently construct chiral C(sp3)—C(sp2)bonds.The key to the success is the use of copper/rationally designed chiral ligand catalytic system for not only efficiently initiating the reaction,but also achieving the challenging enantiocontrol over the highly reactive radical species.In this perspective,we have summarized the impact of the development of two types of chiral ligands and anticipate further development in the research field.
关键词
铜催化剂/自由基/不对称/有机硼试剂/手性配体Key words
copper catalyst/radical/asymmetric/organoboron reagents/chiral ligand引用本文复制引用
基金项目
National Natural Science Foundation of China(22025103)
National Natural Science Foundation of China(22201127)
National Natural Science Foundation of China(22101122)
出版年
2024
NETL
NSTL
万方数据