双金属混配体型金属有机框架材料在电化学生物分子检测中的应用
Bimetallic mixed-linker metal-organic frameworks for electrochemical detection of biomolecules
于瑷瑄 1郝存迪 1杨春蕾 1刘情 1李佳佳 1薄祥洁 1杜东英 1苏忠民2
作者信息
- 1. 东北师范大学化学学院,吉林长春 130024
- 2. 海南大学化学工学院,海南海口 570228
- 折叠
摘要
近年来,由于金属有机框架材料在结构、孔隙率和微环境等方面的可调性,其在多个领域备受关注.抗坏血酸(AA)、多巴胺(DA)和尿酸(UA)的检测不仅在生物医学和神经化学领域,而且在疾病诊断和病理研究中均具有重要意义.本文成功合成了 一系列双金属有机框架材料,MIL-125(Ti-Fe)-x％NH2(x=0,25,50,75 和 100),作为检测 AA,DA 和UA 的电化学传感器.在 0.1mol·L-1 PBS(pH=7.10)电解液中,MIL-125(Ti-Fe)-100％NH2掺杂50％炭黑作为电极修饰材料时表现出最理想的性能.此外,制备的MIL-125(Ti-Fe)-100％NH2/GCE具有优异的抗干扰性能和良好的稳定性,为其在实际样品分析中提供了良好的平台.
Abstract
Because of their easy tunability in structure,porosity,and micro-environment,metal-organic frameworks(MOFs)have recently attracted numerous attentions in various fields.The detection of ascor-bic acid(AA),dopamine(DA),and uric acid(UA)is of great significance not only in biomedicine and neurochemistry but also in disease diagnosis and pathology research.Herein,a series of bimetallic-organic frameworks,MIL-125(Ti-Fe)-x％NH2(x=0,25,50,75,and 100),was successfully synthesized.MIL-125(Ti-Fe)-x％NH2 family was employed as electrochemical sensors for the detection of AA,DA,and UA,and MIL-125(Ti-Fe)-100％NH2 exhibited the most promising performance with 50％carbon black doping in 0.1 mol·L-1 PBS(pH=7.10).In addition,the as-prepared MIL-125(Ti-Fe)-100％NH2/GCE exhibited excellent anti-interference performance and good stability,which provided a promising platform for future utilization in real sample analysis.
关键词
金属有机框架/生物分子检测/电化学传感Key words
metal-organic frameworks/biomolecule detection/electrochemical sensors引用本文复制引用
基金项目
Natural Science Foundation of Science and Technology Department of Jilin Province(20210101131JC)
Fundamental Research Funds for the Central Universities(2412020FZ009)
Fundamental Research Funds for the Central Universities(2412022ZD048)
出版年
2024
NETL
NSTL
万方数据