首页|双金属混配体型金属有机框架材料在电化学生物分子检测中的应用

双金属混配体型金属有机框架材料在电化学生物分子检测中的应用

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近年来，由于金属有机框架材料在结构、孔隙率和微环境等方面的可调性，其在多个领域备受关注。抗坏血酸(AA)、多巴胺(DA)和尿酸(UA)的检测不仅在生物医学和神经化学领域，而且在疾病诊断和病理研究中均具有重要意义。本文成功合成了 一系列双金属有机框架材料，MIL-125(Ti-Fe)-x％NH2(x=0，25，50，75 和 100)，作为检测 AA，DA 和UA 的电化学传感器。在 0。1mol·L-1 PBS(pH=7。10)电解液中，MIL-125(Ti-Fe)-100％NH2掺杂50％炭黑作为电极修饰材料时表现出最理想的性能。此外，制备的MIL-125(Ti-Fe)-100％NH2/GCE具有优异的抗干扰性能和良好的稳定性，为其在实际样品分析中提供了良好的平台。
Bimetallic mixed-linker metal-organic frameworks for electrochemical detection of biomolecules
Because of their easy tunability in structure,porosity,and micro-environment,metal-organic frameworks(MOFs)have recently attracted numerous attentions in various fields.The detection of ascor-bic acid(AA),dopamine(DA),and uric acid(UA)is of great significance not only in biomedicine and neurochemistry but also in disease diagnosis and pathology research.Herein,a series of bimetallic-organic frameworks,MIL-125(Ti-Fe)-x％NH2(x=0,25,50,75,and 100),was successfully synthesized.MIL-125(Ti-Fe)-x％NH2 family was employed as electrochemical sensors for the detection of AA,DA,and UA,and MIL-125(Ti-Fe)-100％NH2 exhibited the most promising performance with 50％carbon black doping in 0.1 mol·L-1 PBS(pH=7.10).In addition,the as-prepared MIL-125(Ti-Fe)-100％NH2/GCE exhibited excellent anti-interference performance and good stability,which provided a promising platform for future utilization in real sample analysis.

metal-organic frameworksbiomolecule detectionelectrochemical sensors

于瑷瑄、郝存迪、杨春蕾、刘情、李佳佳、薄祥洁、杜东英、苏忠民

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东北师范大学化学学院,吉林长春 130024

海南大学化学工学院,海南海口 570228

金属有机框架 生物分子检测 电化学传感

Natural Science Foundation of Science and Technology Department of Jilin ProvinceFundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities

20210101131JC2412020FZ0092412022ZD048

2024

10.13563/j.cnki.jmolsci.2024.04.005

分子科学学报
中国化学会

分子科学学报

CSTPCD
影响因子：0.434
ISSN：1000-9035
年,卷(期)：2024.40(2)
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