首页|Plant RNA-binding proteins:Phase separation dynamics and functional mechanisms underlying plant development and stress responses

Plant RNA-binding proteins:Phase separation dynamics and functional mechanisms underlying plant development and stress responses

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RNA-binding proteins(RBPs)accompany RNA from synthesis to decay,mediating every aspect of RNA metabolism and impacting diverse cellular and developmental processes in eukaryotes.Many RBPs un-dergo phase separation along with their bound RNA to form and function in dynamic membraneless biomolecular condensates for spatiotemporal coordination or regulation of RNA metabolism.Increasing evidence suggests that phase-separating RBPs with RNA-binding domains and intrinsically disordered re-gions play important roles in plant development and stress adaptation.Here,we summarize the current knowledge about how dynamic partitioning of RBPs into condensates controls plant development and en-ables sensing of experimental changes to confer growth plasticity under stress conditions,with a focus on the dynamics and functional mechanisms of RBP-rich nuclear condensates and cytoplasmic granules in mediating RNA metabolism.We also discuss roles of multiple factors,such as environmental signals,pro-tein modifications,and N6-methyladenosine RNA methylation,in modulating the phase separation behav-iors of RBPs,and highlight the prospects and challenges for future research on phase-separating RBPs in crops.

RNA-binding proteinsphase separationbiomolecular condensatesRNA metabolismdevelopmentstress resilience

Sheng Fan、Yu Zhang、Shaobo Zhu、Lisha Shen

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Temasek Life Sciences Laboratory,1 Research Link,National University of Singapore,1 Research Link,Singapore 117604,Singapore

Department of Biological Sciences,National University of Singapore,14 Science Drive 4,Singapore 117543,Singapore

National Research Foundation Competitive Research Programmeintramural funding from Temasek Life Sciences Laboratory

NRF-CRP22-2019-0001

2024

10.1016/j.molp.2024.02.016

分子植物(英文版)
中科院上海生命科学研究院植物生理生态所　中国植物生理学会

分子植物(英文版)

CSTPCD
影响因子：0.659
ISSN：1674-2052
年,卷(期)：2024.17(4)
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