首页|The MYC2-PUB22-JAZ4 module plays a crucial role in jasmonate signaling in tomato

The MYC2-PUB22-JAZ4 module plays a crucial role in jasmonate signaling in tomato

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Jasmonates(JAs),a class of lipid-derived stress hormones,play a crucial role across an array of plant phys-iological processes and stress responses.Although JA signaling is thought to rely predominantly on the degradation of specific JAZ proteins by SCFCOI1,it remains unclear whether other pathways are involved in the regulation of JAZ protein stability.Here,we report that PUB22,a plant U-box type E3 ubiquitin ligase,plays a critical role in the regulation of plant resistance against Helicoverpa armigera and other JA re-sponses in tomato.Whereas COI1 physically interacts with JAZ1/2/5/7,PUB22 physically interacts with JAZ1/3/4/6.PUB22 ubiquitinates JAZ4 to promote its degradation via the 26S proteasome pathway.Impor-tantly,we observed that pub22 mutants showreduced resistance to H.armigera,whereasjaz4 single mu-tants and jaz1 jaz3 jaz4 jaz6 quadruple mutants have enhanced resistance.The hypersensitivity of pub22 mutants to herbivores could be partially rescued by JAZ4 mutation.Moreover,we found that expression of PUB22 can be transcriptionally activated by MYC2,thus forming a positive feedback circuit in JA signaling.We noticed that the PUB22-JAZ4 module also regulates other JA responses,including defense against B.cinerea,inhibition of root elongation,and anthocyanin accumulation.Taken together,these re-sults indicate that PUB22 plays a crucial role in plant growth and defense responses,together with COI1-regulated JA signaling,by targeting specific JAZs.

PUB22JAZCOI1MYC2JA signalingSolanum lycopersicum

Shaofang Wu、Chaoyi Hu、Changan Zhu、Yanfen Fan、Jie Zhou、Xiaojia Xia、Kai Shi、Yanhong Zhou、Christine H.Foyer、Jingquan Yu

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Department of Horticulture,Zijingang Campus,Zhejiang University,Hangzhou 310058,China

Hainan Institute,Zhejiang University,Yazhou Bay Science and Technology City,Sanya 572025,China

College of Horticulture,Northwest Agriculture & Forestry University,Xianyang 712100,China

School of Biosciences,College of Life and Environmental Sciences,University of Birmingham,Edgbaston B15 2TT,UK

Key Laboratory of Horticultural Plants Growth and Development,Agricultural Ministry of China,Zhejiang University,Hangzhou 310058,China

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National Natural Science Foundation of China Projects of International Cooperation and Exchange国家自然科学基金Modern Agroindustry Technology Research System of China

3202010301332302532CARS-25-02A

2024

10.1016/j.molp.2024.02.006

分子植物(英文版)
中科院上海生命科学研究院植物生理生态所　中国植物生理学会

分子植物(英文版)

CSTPCD
影响因子：0.659
ISSN：1674-2052
年,卷(期)：2024.17(4)
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