首页|SMXL5 attenuates strigolactone signaling in Arabidopsis thaliana by inhibiting SMXL7 degradation

SMXL5 attenuates strigolactone signaling in Arabidopsis thaliana by inhibiting SMXL7 degradation

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Hormone-activated proteolysis is a recurring theme of plant hormone signaling mechanisms.In strigolac-tone signaling,the enzyme receptor DWARF14(D14)and an F-box protein,MORE AXILLARY GROWTH2(MAX2),mark SUPPRESSOR OF MAX21-LIKE(SMXL)family proteins SMXL6,SMXL7,and SMXL8 for rapid degradation.Removal of these transcriptional corepressors initiates downstream growth responses.The homologous proteins SMXL3,SMXL4,and SMXL5,however,are resistant to MAX2-mediated degradation.We discovered that the smxl4 smxl5 mutant has enhanced responses to strigolactone.SMXL5 attenuates strigolactone signaling by interfering with AtD14-SMXL7 interactions.SMXL5 interacts with AtD14 and SMXL7,providing two possible ways to inhibit SMXL7 degradation.SMXL5 function is partially dependent on an ethylene-responsive-element binding-factor-associated amphiphilic repression(EAR)motif,which typically mediates interactions with the TOPLESS family of transcriptional corepressors.However,we found that loss of the EAR motif reduces SMXL5-SMXL7 interactions and the attenuation of strigolactone signaling by SMXL5.We hypothesize that integration of SMXL5 into heteromeric SMXL complexes reduces the susceptibility of SMXL6/7/8 proteins to strigolactone-activated degradation and that the EAR motif pro-motes the formation or stability of these complexes.This mechanism may provide a way to spatially or temporally fine-tune strigolactone signaling through the regulation of SMXL5 expression or translation.

Qingtian Li、Haiyang Yu、Wenwen Chang、Sunhyun Chang、Michael Guzmán、Lionel Faure、Eva-Sophie Wallner、Heqin Yan、Thomas Greb、Lei Wang、Ruifeng Yao、David C.Nelson

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Department of Botany and Plant Sciences,University of California,Riverside,Riverside,CA 92521,USA

Yazhouwan National Laboratory,Sanya 572025,China

Hainan Seed Industry Laboratory,Sanya 57205,China

State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan Provincial Key Laboratory of Plant Functional Genomics and Developmental Regulation,College of Biology,Hunan University,Changsha 410082,China

Key Laboratory of Seed Innovation,Center for Agricultural Resources Research,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Shijiazhuang,Hebei 050021,China

University of Chinese Academy of Sciences,Beijing 100049,China

School of the Sciences,Biology Division,Texas Woman's University,Denton,TX 76204,USA

Centre for Organismal Studies(COS),Heidelberg University,69120 Heidelberg,Germany

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National Science Foundation,Division of Integrative Organismal SystemsNational Science Foundation,Division of Integrative Organismal SystemsNational Science Foundation,Division of Integrative Organismal SystemsHainan Seed Industry Laboratory国家重点研发计划国家自然科学基金Shenzhen Science and Technology Innovation Commission国家自然科学基金河北省自然科学基金德意志研究联合会项目

173715317405601856741B23C197012021YFA1300400320703212021Szvup03732170320C2022503003GR 2104/9-1

2024

10.1016/j.molp.2024.03.006

分子植物(英文版)
中科院上海生命科学研究院植物生理生态所　中国植物生理学会

分子植物(英文版)

CSTPCD
影响因子：0.659
ISSN：1674-2052
年,卷(期)：2024.17(4)
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