首页|FERONIA-mediated TIR1/AFB2 oxidation stimulates auxin signaling in Arabidopsis

FERONIA-mediated TIR1/AFB2 oxidation stimulates auxin signaling in Arabidopsis

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The phytohormone auxin plays a pivotal role in governing plant growth and development.Although the TRANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F-BOX(TIR1/AFB)receptors function in both the nucleus and cytoplasm,the mechanism governing the distribution of TIR1/AFBs between these cellular compartments remains unknown.In this study,we demonstrate that auxin-mediated oxidation of TIR1/AFB2 is essential for their targeting to the nucleus.We showed that small active molecules,reactive oxygen species(ROS)and nitric oxide(NO),are indispensable for the nucleo-cytoplasmic distribution of TIR1/AFB2 in trichoblasts and root hairs.Further studies revealed that this process is regulated by the FERONIA receptor kinase-NADPH oxidase signaling pathway.Interestingly,ROS and NO initiate oxidative modifica-tions in TIR1C140/516 and AFB2C135/511,facilitating their subsequent nuclear import.The oxidized forms of TIR1C140/516 and AFB2C135/511 play a crucial role in enhancing the function of TIR1 and AFB2 in transcrip-tional auxin responses.Collectively,our study reveals a novel mechanism by which auxin stimulates the transport of TIR1/AFB2 from the cytoplasm to the nucleus,orchestrated by the FERONIA-ROS signaling pathway.

FERONIATIR1/AFBsoxidative modificationnucleo-cytoplasmic distributionroot hair development

Baiyan Lu、Shengnan Wang、Hanqian Feng、Jing Wang、Kaixing Zhang、Yilin Li、Ping Wu、Minmin Zhang、Yanshu Xia、Chao Peng、Chao Li

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School of Life Sciences,East China Normal University,Shanghai 200241,China

National Facility for Protein Science Shanghai,Zhangjiang Lab,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai 201210,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaScience and Technology Innovation Plan Of Shanghai Science and Technology Commission

32230009317703073197286320ZR1416500

2024

10.1016/j.molp.2024.04.002

分子植物(英文版)
中科院上海生命科学研究院植物生理生态所　中国植物生理学会

分子植物(英文版)

CSTPCD
影响因子：0.659
ISSN：1674-2052
年,卷(期)：2024.17(5)