首页|Plant triterpenoid saponins function as susceptibility factors to promote the pathogenicity of Botrytis cinerea
Plant triterpenoid saponins function as susceptibility factors to promote the pathogenicity of Botrytis cinerea
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The gray mold fungus Botrytis cinerea is a necrotrophic pathogen that causes diseases in hundreds of plant species,including high-value crops.Its polyxenous nature and pathogenic success are due to its ability to perceive host signals in its favor.In this study,we found that laticifer cells of Euphorbia lathyris are a source of susceptibility factors required by B.cinerea to cause disease.Consequently,poor-in-latex(pil)mutants,which lack laticifer cells,show full resistance to this pathogen,whereas Iot-of-latex mutants,which produce more laticifer cells,are hypersusceptible.These S factors are triterpenoid saponins,which are widely distributed natural products of vast structural diversity.The downregulation of laticifer-specific oxy-dosqualene cyclase genes,which encode the first committed step enzymes for triterpene and,therefore,saponin biosynthesis,conferred disease resistance to B.cinerea.Likewise,the Medicago truncatula Iha-1 mutant,compromised in triterpenoid saponin biosynthesis,showed enhanced resistance.Interestingly,the application of different purified triterpenoid saponins pharmacologically complemented the disease-resistant phenotype of pil and hla-1 mutants and enhanced disease susceptibility in different plant species.We found that triterpenoid saponins function as plant cues that signal transcriptional reprogramming in B.cinerea,leading to a change in its growth habit and infection strategy,culminating in the abundant for-mation of infection cushions,the multicellular appressoria apparatus dedicated to plant penetration and biomass destruction in B.cinerea.Taken together,these results provide an explanation for how plant tri-terpenoid saponins function as disease susceptibility factors to promote B.cinerea pathogenicity.
Euphorbia lathyrislaticifer celllatexappressoriuminfection cushionnecrotrophic fungi
Francisco J.Escaray、Amelia Felipo-Benavent、Cristian J.Antonelli、Bego?a Balaguer、Maria Pilar Lopez-Gresa、Pablo Vera
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Instituto de Biología Molecular y Celular de Plantas,Universidad Politécnica de Valencia-C.S.I.C,Ciudad Politécnica de la Innovación,Edificio 8E,acceso G,Ingeniero Fausto Elio,s/n,46022 Valencia,Spain
Spanish AEI research agencySpanish AEI research agency
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