Genomic and metabolomic insights into the selection and differentiation of bioactive compounds in citrus

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外文摘要：Bioactive compounds play an increasingly prominent role in breeding functional and nutritive fruit crops such as citrus.However,the genomic and metabolic bases for the selection and differentiation underly-ing bioactive compound variations in citrus remain poorly understood.In this study,we constructed a species-level variation atlas of genomes and metabolomes using 299 citrus accessions.A total of 19 829 significant SNPs were targeted to 653 annotated metabolites,among which multiple significant signals were identified for secondary metabolites,especially flavonoids.Significant differential accumu-lation of bioactive compounds in the phenylpropane pathway,mainly flavonoids and coumarins,was un-veiled across ancestral citrus species during differentiation,which is likely associated with the divergent haplotype distribution and/or expression profiles of relevant genes,including p-coumaroyl coenzyme A 2'-hydroxylases,flavone synthases,cytochrome P450 enzymes,prenyltransferases,and uridine diphos-phate glycosyltransferases.Moreover,we systematically evaluated the beneficial bioactivities such as the antioxidant and anticancer capacities of 219 citrus varieties,and identified robust associations be-tween distinct bioactivities and specific metabolites.Collectively,these findings provide citrus breeding options for enrichment of beneficial flavonoids and avoidance of potential risk of coumarins.Our study will accelerate the application of genomic and metabolic engineering strategies in developing modern healthy citrus cultivars.

外文关键词：

citrusmetabolomegenome-wide association studybioactive compounds

作者：

Xiao Liang、Yue Wang、Wanxia Shen、Bin Liao、Xiaojuan Liu、Zimeng Yang、Jiebiao Chen、Chenning Zhao、Zhenkun Liao、Jinping Cao、Ping Wang、Peng Wang、Fuzhi Ke、Jianguo Xu、Qiong Lin、Wanpeng Xi、Lishu Wang、Juan Xu、Xiaochun Zhao、Chongde Sun

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作者单位：

Plant Growth,Development and Quality Improvement,Zhejiang Provincial Key Laboratory of Integrative Biology of Horticultural Plants,Zhejiang University,Hangzhou,China

Citrus Research Institute,Southwest University/Chinese Academy of Agricultural Sciences,Chongqing,China

Hainan Institute of Zhejiang University,Sanya,China

Zhejiang Citrus Research Institute,Taizhou,China

Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process,Ministry of Agriculture and Rural Affairs/Institute of Food Science and Technology,Chinese Academy of Agricultural Sciences,Beijing,China

College of Horticulture and Landscape Architecture,Southwest University,Chongqing,China

Department of Hematology and Hematopoietic Cell Transplantation,Comprehensive Cancer Center,City of Hope National Medical Center,Duarte,CA,USA

Key Laboratory of Horticultural Plant Biology(Ministry of Education),Huazhong Agricultural University,Wuhan,China

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出版年：

2024

DOI：

10.1016/j.molp.2024.10.009

分子植物(英文版)

中科院上海生命科学研究院植物生理生态所　中国植物生理学会

分子植物(英文版)

CSTPCD

影响因子：0.659

ISSN：1674-2052

年,卷(期)：2024.17(11)