Analysis of Anti-fatigue Mechanism of Phyllanthin,the Active Component of Phyllanthus amarus
This study investigates the anti-fatigue mechanism of phyllanthin,the primary active component of Phyllathus amarus(also known as bitter leaf pearl).The research indicates that phyllanthin notably enhances the exhaustive swimming duration of EIF rats and effectively reduces the levels of serum cardiac injury markers,demonstrating its significant anti-EIF activity.Mechanistic studies reveal that Phyllanthin exerts its anti-fatigue effects by activating Nrf2,thereby elevating the levels of antioxidant enzymes and reducing ROS production,subsequently providing cellular protection.Moreover,phyllanthin also optimizes energy metabolism,reducing fatigue levels.This research provides a scientific basis for the development of anti-fatigue health products based on Phyllanthin.
NETL
NSTL
万方数据
维普
