Impact of Soy-Derived Stigmasterol on the Gut Microbiota and Energy Metabolism of Exercise-Induced Fatigue in Rats
This study aims to explore the impact of soy-derived stigmasterol on the gut microbiota and energy metabolism in rats with exercise-induced fatigue.Rats with exercise-induced fatigue exhibited signs of fatigue alle-viation following treatment with stigmasterol,manifested by an extension of exhaustion time and a reduction in in-dicators of myocardial injury.Further research revealed that stigmasterol could significantly adjust the balance of gut microbiota,reducing the abundance of Firmicutes and increasing the abundance of Bacteroidetes.Moreover,stigmasterol was also able to upregulate energy metabolism-related genes,such as SIRT1,PGC-1α,HK2,MCT-1,and NRF-1,elevate glycogen and Glu levels,and reduce LA and BUN levels,thereby improving the energy metabolism status and alleviating exercise-induced fatigue.The results of this study unveil the potential application value of stigmasterol in the prevention and alleviation of exercise-induced fatigue,providing new insights for its development in the fields of food and medicine.
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万方数据
维普
