Fucoxanthin Extracted from Brown Seaweed Alleviates Exercise-Induced Fatigue
Fucoxanthin,a natural extract from brown seaweed,has garnered scientific attention in recent years,especially in the anti-fatigue domain.As a substance with potent antioxidant properties,it has been proven to significantly reduce oxidative damage post-exercise and effectively mitigate fatigue.In this study,rats were divided into six groups,including a control group,an EIF model group,different dosages of fucoxanthin treatment groups,and a combined treatment group of fucoxanthin and Nrf2 inhibitor ML385.After a 4-week experiment,results showed that compared to the EIF model group,the fucoxanthin-treated groups significantly extended their exhaustive swimming time.Concurrently,the serum levels of LDH,CK,and cTnI decreased,while the antioxidative enzymes in skeletal muscle such as SOD,CAT,and GSH-Px increased in activity and MDA levels dropped.Moreover,fucoxanthin treatment upregulated the expression of Nrf2 and its downstream target genes HO-1 and NQO-1,while suppressing Keap1 expression.However,when the Nrf2 inhibitor ML385 was applied,the anti-EIF effects and activation of the Nrf2-ARE pathway brought by fucoxanthin were inhibited.In conclusion,fucoxanthin effectively alleviates EIF through the activation of the Nrf2-ARE pathway,showing its potential as a highly effective anti-EIF health component.Evidently,fucoxanthin holds promise as a crucial natural ingredient in the future anti-fatigue domain,with potential widespread applications in sports supplements or food additives.
Brown seaweedFucoxanthinExercise-induced fatigueNrf2-ARE mechanismAntioxidant
NETL
NSTL
万方数据
维普
