Effects of Smilapogenin on Rats with Cognitive Impairment Induced by High-fat Diet
This study aims to investigate the effects of A nemarrhena asphodeloides Bunge-derived Sarsasapogenin on cognitive function in high-fat diet-induced cognitive impairment rats and further explore its potential me-chanisms.Using methods including the Morris water maze test,Nissl staining,and enzyme-linked immunosorbent assay,our study found that pre-exercise supplementation of sarsasapogenin significantly reduced the escape latency and increased the number of platform crossings in high-fat diet-induced rats.This supplementation also alleviated hippocampal neuronal damage.Furthermore,sarsasapogenin supplementation inhibited hippocampal inflammation by reducing the levels of IL-1 β,IL-6,and TNF-α.The activation of NF-κB is a key factor in high-fat diet-induced neuroinflammation,and sarsasapogenin was found to decrease the phosphorylation of NF-κB,thereby suppressing the inflammatory response.Additionally,our study observed that sarsasapogenin downregulated the expression of B ACE 1,reducing the generation of Aβ 1-42,providing a molecular basis for the improvement of cognitive function.In summary,our study emphasizes the potential applications and mechanisms of pre-exercise sarsasapogenin sup-plementation in ameliorating high-fat diet-induced cognitive impairment.
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万方数据
维普
