Effects of Fisetin on Apoptosis and Mitochondrial Function of Skeletal Mus-cle Cells in Exhausted Exercise Rats
Fisetin(FIS)is a dietary flavonoid derived from various fruits,vegetables,and nuts.It is a consistent dietary nutritional supplement.This study aimed to investigate the impact of strawberry-derived fisetin on apopto-sis and mitochondrial function in the skeletal muscle cells of exhaustive exercise-induced rats.Exhaustive exercise is typically accompanied by inflammatory responses and oxidative stress,leading to skeletal muscle damage and mitochondrial dysfunction.Fisetin has been extensively studied and is considered to have antioxidant and anti-in-flammatory properties.This study utilized an exhaustive exercise-induced rat model to examine the protective ef-fects of fisetin.The results showed that fisetin treatment significantly reduced the peripheral inflammation induced by exhaustive exercise and inhibited skeletal muscle cell apoptosis.Furthermore,fisetin dose-dependently in-creased skeletal muscle mitochondrial enzyme activity,improved mitochondrial respiratory function,and promot-ed mitochondrial biogenesis.These findings suggest that strawberry-derived fisetin may serve as a potential dietary supplement for exercise,contributing to the maintenance of skeletal muscle health and mitochondrial function.
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万方数据
维普
