Impact of Plant-Derived Sinapinic Acid Combined with Exercise on Non-Alcoholic Fatty Liver in Rats
This study investigated the impact of combined treatment with plant-derived sinapinic acid and exer-cise on the transcription of lipid metabolism genes in non-alcoholic fatty liver disease(NAFLD)rats.An NAFLD rat model was induced using a high-fat diet(HFD)and divided into different intervention groups,including single applications of sinapinic acid,exercise,combined sinapinic acid and exercise,and a control group.The results demonstrated that the combined treatment significantly reduced body weight,improved liver function,and de-creased hepatic fat content in NAFLD rats.At the molecular level,in the sinapinic acid combined with exercise group,mRNA levels of lipid metabolism genes,including SREBP1c,FAS,and ACC-1,were significantly down-regulated,while mRNA levels of CPT-1,CYP7A1,and FXR were significantly upregulated,thereby correcting the transcriptional dysregulation of hepatic lipid metabolism genes.Furthermore,the combined treatment group exhib-ited significantly increased activities of the antioxidant enzymes SOD and CAT,decreased levels of the oxidative damage marker MDA,and a significant reduction in inflammatory factors TNF-α,IL-1β,and IL-6.This compre-hensive effect indicates that plant-derived sinapinic acid combined with exercise treatment improves the pathologi-cal processes of NAFLD through multiple mechanisms.These findings provide strong support for the development of NAFLD treatment strategies.
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