Piperine in Pepper,Improves Exercise-induced Skeletal Muscle Damage in Rats by Regulating the PI3K/AKT Pathway
With the increasing prominence of exercise-induced skeletal muscle damage(EISMD),the search for effective therapeutic interventions becomes urgent.This study focuses on piperine,an active compound in pepper,gamering attention due to its diverse physiological activities.However,the exact mechanism of its action in EIS-MD remains not fully understood.By establishing an EISMD rat model,this study systematically investigated the therapeutic effects of piperine,with a particular emphasis on exploring whether it improves EISMD by modulating the PI3K/AKT signaling pathway.The experimental results demonstrate that piperine treatment significantly alle-viated muscle damage in EISMD rats,concurrently reducing inflammatory mediators in serum and suppressing ox-idative stress.Furthermore,by enhancing ATP levels,piperine facilitated cellular energy metabolism.In-depth mechanistic studies revealed that piperine may exert its protective effects by activating the PI3K/AKT signaling pathway to inhibit cell apoptosis.In summary,piperine exhibits multifaceted actions,including anti-inflammatory,antioxidant,and anti-apoptotic effects,laying an experimental foundation for its potential use as a therapeutic agent for EISMD.
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