Origanum majorana L.,commonly known as sweet marjoram,is a fragrant perennial herb used as a culinary spice and also valued for its anti-inflammatory and antioxidant medicinal properties.Recent studies have indicated that Origanum majorana L.extract may offer preventive benefits against myocardial infarction.This study aims to investigate the effects of Origanum majorana extract(OME)combined with resistance exercise(RE)on myocardial ischemia/reperfusion(I/R)injury in rats with myocardial infarction.The experiment was divided into Sham,MI(Myocardial Infarction),RE,L-OME(Low-dose OME),M-OME(Medium-dose OME),H-OME(High-dose OME),and RE+H-OME groups.The results demonstrated that OME combined with RE significantly reduced myocardial infarction size,improved myocardial morphology,and alleviated myocardial oxidative stress and in-flammation.Additionally,this combined intervention significantly reduced the proportion of TUNEL-positive my-ocardial cells and decreased myocardial cell apoptosis.On the molecular level,OME combined with RE signifi-cantly increased the expression of Notch 1 and Hes1 in the myocardium.These findings suggest that OME com-bined with RE could serve as a potential therapeutic strategy to alleviate post-myocardial infarction myocardial I/R injury through the activation of the Notch 1/Hes1 pathway.This study provides a new perspective on myocardial protection after myocardial infarction and lays a foundation for future clinical research.
维普
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