The Protective Effects of Vaccinium myrtillus Extract and Resistance Exer-cise on Myocardial Ischemia-reperfusion Injury in Rats
Bilberry(Vaccinium myrtillus L.)is rich in anthocyanins,flavonoids,and phenolic acids,compounds with a variety of biological effects,and is widely used in juice and food production or as a dietary supplement.In recent years,increasing research has focused on finding effective cardiac protective strategies to mitigate myocar-dial ischemia-reperfusion injury(MIRI).This study aimed to assess the synergistic cardioprotective effects of Bil-berry extract(Vaccinium myrtillus extract,VME)and resistance exercise(RE)in a rat model of myocardial is-chemia-reperfusion injury.Through comparative analysis across multiple groups,this study investigated the im-pacts of VME and RE on myocardial injury markers,oxidative stress,inflammatory response,myocardial cell apoptosis rate,and the Nrf2/HO-1 signaling pathway.The results showed that combined treatment with VME and RE significantly reduced the rate of myocardial cell apoptosis and decreased the expression of inflammatory mark-ers TNF-α,CRP,and IL-6 while increasing antioxidant enzyme activity and activating the Nrf2/HO-1 signaling pathway.These findings suggest that Bilberry extract combined with resistance exercise may exert cardioprotective effects by alleviating oxidative stress and inflammatory responses,as well as activating the Nrf2/HO-1 pathway.This study highlights the potential of Bilberry extract as a promising cardiac protective agent,offering a new per-spective for the treatment of cardiovascular diseases with its natural origin and multiple protection mechanisms.
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