Study on the Effect of Hesperidin from Citrus Peel Combined with Aerobic Interval Exercise on PM2.5-Induced Lung Injury in Rats
Hesperidin(HES)is a flavonoid substance widely found in citrus peels,known for its significant anti-inflammatory,antioxidant,and organ-protective effects.Long-term consumption of hesperidin also promotes hu-man health.This study aimed to investigate the therapeutic effects of hesperidin combined with aerobic interval exercise on lung injury induced by PM2.5 in rats,and its potential mechanism in regulating the TLR4/MyD88/NF-κB signaling pathway.A PM2.5 particle exposure rat model was used,and the expression levels of TLR4,MyD88,and p-NF-κB p65 proteins in lung tissues of rats from different experimental groups were compared to as-sess the therapeutic effects of hesperidin and aerobic interval exercise.The results showed that both hesperidin treatment and aerobic interval exercise could significantly reduce the expression of TLR4,MyD88,and p-NF-κB p65 compared to the group exposed only to PM2.5,thereby alleviating lung inflammation.Among these,the com-bined intervention of hesperidin and aerobic interval exercise had the most significant effect.These findings sug-gest that hesperidin combined with aerobic interval exercise can effectively reduce lung injury caused by PM2.5,possibly related to its regulation of the TLR4/MyD88/NF-κB signaling pathway.This study provides new strate-gies and theoretical basis for the prevention and treatment of PM2.5-related lung diseases.
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