首页|蕨麻正丁醇提取物与有氧运动对高血压大鼠心肌纤维化调控机制

蕨麻正丁醇提取物与有氧运动对高血压大鼠心肌纤维化调控机制

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
蕨麻(Potentilla anserina L.,PA)具有很高的营养价值和医疗保健功能,有很大的开发利用潜力.蕨麻正丁醇提取物(Potentilla anserina L.n-butanol extract,PABE)具有心脏保护作用.本研究旨在探讨蕨麻正丁醇提取物(PABE)与有氧运动(RE)协同作用对自发性高血压(SHR)大鼠心肌纤维化的影响及其潜在机制.通过设立正常对照组、单独高血压组、单独运动组、不同剂量PABE组以及PABE联合运动组,本研究通过RT-qPCR 技术检测了 心肌纤维化标志物 α-SMA、collagen Ⅰ、collagen Ⅲ、MMP-2、MMP-9 及 TIMP-1 的mRNA表达水平,评估了 PABE与RE对心肌纤维化的调控效果.结果显示,与高血压模型组相比,PABE处理组和运动组均能显著降低α-SMA、collagen Ⅰ、collagen Ⅲ、MMP-2和MMP-9的表达,提高TIMP-1的表达,其中PABE与RE的联合应用效果更为显著.这表明蕨麻正丁醇提取物与有氧运动的结合更有效地抑制了高血压大鼠心肌纤维化的进展,可能通过调节心肌细胞外基质重塑相关基因的表达来发挥作用.本研究为高血压心肌纤维化的综合治疗提供了新的策略和理论依据.
Regulatory Mechanism of P.anserina n-Butanol Extract and Aerobic Exercise on Myocardial Fibrosis in Rats with Hypertension
Potentilla anserina L.(PA)holds significant nutritional and healthcare value,offering substantial poten-tial for development and utilization.The n-butanol extract of Potentilla anserina L.(PABE)has been shown to pro-tect the heart.This study aims to explore the effects and potential mechanisms of the combined action of PABE and aerobic exercise(RE)on myocardial fibrosis in spontaneously hypertensive rats(SHR).By establishing control groups,hypertension-only groups,exercise-only groups,various dosage PABE groups,and combined PABE and exercise groups,this study assessed the regulatory effects of PABE and RE on myocardial fibrosis by measuring the mRNA expression levels of myocardial fibrosis markers α-SMA,collagen Ⅰ,collagen Ⅲ,MMP-2,MMP-9,and TIMP-1 through RT-qPCR technology.The results showed that compared to the hypertension model group,both the PABE treatment groups and exercise groups significantly reduced the expression of α-SMA,collagen Ⅰ,col-lagen Ⅲ,MMP-2,and MMP-9,and increased the expression of TIMP-1,with the combined application of PABE and RE showing even more significant effects.This indicates that the combination of Potentilla anserina L.n-bu-tanol extract and aerobic exercise more effectively inhibited the progression of myocardial fibrosis in hypertensive rats,possibly by regulating the expression of genes related to myocardial extracellular matrix remodeling.This study provides new strategies and theoretical basis for the comprehensive treatment of hypertension-induced my-ocardial fibrosis.

Potentilla anserina L.Potentilla anserina L.n-butanol extract(PABE)Aerobic exercise(RE)Myocar-dial fibrosisSpontaneously hypertensive rats(SHR)Myocardial extracellular matrix remodeling

杨伟鑫

展开 >

南阳职业学院体育学院,南阳,474550

蕨麻(Potentilla anserina L.) 蕨麻正丁醇提取物(PABE) 有氧运动(RE) 心肌纤维化 自发性高血压大鼠(SHR) 心肌细胞外基质重塑

河南省高校人文社会科学研究一般项目河南省高等学校重点科研项目河南省社科联调研课题

2023-ZZJH-28523B890010SKL-2023-716

2024

10.13271/j.mpb.022.004776

分子植物育种
海南省生物工程协会

分子植物育种

CSTPCD北大核心
影响因子：0.765
ISSN：1672-416X
年,卷(期)：2024.22(14)