Study on the Neuroprotective Effects of Butterfly Pea Extract Combined with Exercise in a Rat Model of Parkinson's Disease
This study aims to explore the neuroprotective effects of Clitoria ternatea Linn.extract(CTE)in com-bination with exercise on a rat model of Parkinson's disease(PD).Different dosages of CTE and exercise training were administered to PD model rats to observe their effects on behavioral performance,midbrain structure,and key neural pathways.The results demonstrated that the combined application of CTE and exercise significantly im-proved motor function in rats,alleviated midbrain neuronal damage,and exerted a synergistic effect in increasing the expression of tyrosine hydroxylase(TH)and decreasing the expression of α-synuclein(α-Syn).Additionally,the combined treatment upregulated the expression of the antioxidative factor Nrf2 in the midbrain and inhibited the activation of the inflammatory factor NF-κB.The study revealed that CTE combined with exercise exerts neu-roprotective effects through antioxidative and anti-inflammatory pathways,potentially becoming an effective com-ponent of future comprehensive therapeutic strategies for PD.This research provides experimental evidence and theoretical support for the application of CTE and exercise in the treatment of PD.
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