The Therapeutic Effects and Mechanisms of Bupleurum Active Compounds Combined with Aerobic Exercise on Obese Rats
This study aims to explore the therapeutic effects and mechanisms of the active substance Saikosaponin A(SSA)from Bupleurum chinensis,in combination with aerobic exercise on obese rats.An obesity rat model was established to examine the effects of both individual and combined applications of Saikosaponin A and aerobic ex-ercise on the weight,blood lipid levels,liver fat accumulation,and the expression of genes related to fat generation in obese rats.Results indicated that compared to individual treatments,the combination of Saikosaponin A and aerobic exercise significantly reduced the weight and liver fat accumulation in rats,improved lipid parameters,and exerted antioxidant and anti-inflammatory effects by upregulating the activity of antioxidant enzymes and down-regulating pro-inflammatory cytokine levels.Further mechanistic studies revealed that this combined treatment ac-tivates the Nrf2 pathway and inhibits the NF-κB pathway,effectively regulating the expression of genes associated with fat generation.This study confirmed the synergistic effects of Saikosaponin A and aerobic exercise in the treatment of obesity,providing new strategies and insights for comprehensive obesity management.
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