Regulatory Role of Aglycone Naringenin from Grapefruit Extract on Ferroptosis in Exercise-Induced Myocardial Injury
Naringenin(NAR),an aglycone flavonoid abundant in grapefruit,has been extensively studied for its potential antioxidative,anti-inflammatory,anticancer,cardiovascular protective,and antidiabetic effects.It actively participates in various biochemical pathways,regulating enzymatic activity and cell signaling.This study aims to explore how naringenin in grapefruit extract counteracts ferroptosis in exercise-induced myocardial injury(EIMI)through the regulation of the ROS/GSH/GPX4 axis.Through a series of experiments,we confirmed that naringenin effectively reduces the production of reactive oxygen species(ROS)in the myocardium and inhibits ferroptosis by enhancing the activity of glutathione(GSH)and glutathione peroxidase 4(GPX4),thereby protecting the myocar-dium from damage caused by excessive exercise.Additionally,naringenin also demonstrates the potential to regulate the nuclear factor erythroid 2-related factor 2(Nrf2)/System xc-axis,further enhancing the antioxidative defense capabilities of myocardial cells.The findings of this study suggest that naringenin is a potential therapeutic agent for EIMI,providing a scientific basis for the further development of natural product-based strategies for myocardial protection.
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维普
