Effects of Cryptotanshinone Combined with Swimming on PM2.5-Induced Pulmonary Fibrosis and Inflammation in Rats
This study aims to explore the effects of cryptotanshinone(CTS),extracted from Danshen root(Salvia miltiorrhiza),combined with swimming on PM25-induced pulmonary fibrosis and inflammation in rats.The re-search examined the synergistic action of CTS and swimming training on pulmonary tissue morphology and bio-chemical markers by comparing a blank control group,a PM2.5 exposure-only group,various dosages of CTS treat-ment groups,a swimming-only group,and a CTS combined with swimming treatment group.The results indicated that both individual treatments with CTS and swimming significantly mitigated PM25-induced pulmonary tissue damage and inflammatory responses,with the combined treatment of CTS and swimming showing even more pro-nounced effects.Particularly,this combination was notably effective in reducing levels of inflammatory factors such as TNF-α and IL-6,as well as improving antioxidant indicators.Furthermore,both CTS and swimming train-ing effectively upregulated the expression of TRIM72 and Cav1 in the lung tissue,promoting repair of alveolar ep-ithelial cells,thereby preventing the development of pulmonary fibrosis.These findings suggest that combining cryptotanshinone with swimming may be an effective strategy for preventing and treating lung damage caused by PM25 exposure.
Salvia miltiorrhizaCryptotanshinonePM2.5-induced pulmonary fibrosisInflammatory responseSwimming training
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