Effects of Rhubarb Active Ingredients Combined with VT on Biomechanics and Metabolism of Bone in Osteoporotic Rats
This study aimed to investigate the effects of physcion(PHY),a major active component from rhubarb,combined with vibration training(VT)on the biomechanics and bone metabolism in rats with glucocorticoid-induced osteoporosis(OP).An OP rat model was used to evaluate the effects of both individual and combined treatments of PHY and VT on the femoral RANK-RANKL-OPG signaling system,as well as on bone density,bone morphology,and antioxidant enzyme activity.The results showed that combined treatment with PHY and VT significantly increa-sed bone density,improved bone tissue microstructure,reduced the expression of RANK and RANKL,enhanced the levels of OPG,and increased antioxidant enzyme activity while reducing oxidative stress.These findings sug-gest that the combination of physcion and vibration training can effectively improve the biomechanical properties and bone metabolism in glucocorticoid-induced OP rats,offering a potential new strategy for the treatment of OP.
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