This study aimed to investigate the effects of physcion(PHY),a major active component from rhubarb,combined with vibration training(VT)on the biomechanics and bone metabolism in rats with glucocorticoid-induced osteoporosis(OP).An OP rat model was used to evaluate the effects of both individual and combined treatments of PHY and VT on the femoral RANK-RANKL-OPG signaling system,as well as on bone density,bone morphology,and antioxidant enzyme activity.The results showed that combined treatment with PHY and VT significantly increa-sed bone density,improved bone tissue microstructure,reduced the expression of RANK and RANKL,enhanced the levels of OPG,and increased antioxidant enzyme activity while reducing oxidative stress.These findings sug-gest that the combination of physcion and vibration training can effectively improve the biomechanical properties and bone metabolism in glucocorticoid-induced OP rats,offering a potential new strategy for the treatment of OP.
NETL
NSTL
万方数据
