大黄活性成分大黄素甲醚联合振动训练对骨质疏松大鼠骨生物力学和骨代谢的影响
Effects of Rhubarb Active Ingredients Combined with VT on Biomechanics and Metabolism of Bone in Osteoporotic Rats
李利华 1李欢2
作者信息
- 1. 信阳学院公共体育教学部,信阳,464000
- 2. 信阳学院理工学院生物教研室,信阳,464000
- 折叠
摘要
本研究旨在探讨大黄中的主要活性成分大黄素甲醚(PHY)与振动训练(VT)联合应用对糖皮质激素诱导的骨质疏松(OP)大鼠骨生物力学和骨代谢的影响.实验选用OP大鼠模型,通过给予PHY和VT的单独及联合治疗,评估其对股骨RANK-RANKL-OPG信号系统的调节效果以及对骨密度、骨形态和抗氧化酶活性的影响.结果表明,PHY与VT的联合治疗能显著提高OP大鼠的骨密度,改善骨组织微结构,降低RANK和RANKL的表达,提升OPG的水平,同时增强抗氧化酶活性,降低氧化应激.这些发现表明,大黄素甲醚联合振动训练可有效改善因糖皮质激素诱导的OP大鼠的骨生物力学性能和骨代谢状况,为OP的治疗提供了一种潜在的新策略.
Abstract
This study aimed to investigate the effects of physcion(PHY),a major active component from rhubarb,combined with vibration training(VT)on the biomechanics and bone metabolism in rats with glucocorticoid-induced osteoporosis(OP).An OP rat model was used to evaluate the effects of both individual and combined treatments of PHY and VT on the femoral RANK-RANKL-OPG signaling system,as well as on bone density,bone morphology,and antioxidant enzyme activity.The results showed that combined treatment with PHY and VT significantly increa-sed bone density,improved bone tissue microstructure,reduced the expression of RANK and RANKL,enhanced the levels of OPG,and increased antioxidant enzyme activity while reducing oxidative stress.These findings sug-gest that the combination of physcion and vibration training can effectively improve the biomechanical properties and bone metabolism in glucocorticoid-induced OP rats,offering a potential new strategy for the treatment of OP.
关键词
大黄(Rheum/palmatum/L.)/大黄素甲醚/振动训练/骨质疏松/RANK-RANKL-OPG系统/骨生物力学Key words
Rhubarb(Rheum palmatum L.)/Physcion/Vibration training/Osteoporosis/RANK-RANKL-OPG system/Biomechanics引用本文复制引用
出版年
2024
NETL
NSTL
万方数据