Regulatory Effects of Artesunate on Myocardial Iron Metabolism and Ferroptosis-Related Protein Expression in EIMI Rats
Artemisia annua extract,artesunate,is a natural compound with various pharmacological activities,widely used in the treatment of malaria and various inflammatory diseases.This study aims to investigate the ef-fects of artesunate on myocardial iron ion content and ferroptosis-related protein expression in rats with exer-cise-induced myocardial injury.By establishing an animal model of exercise-induced myocardial injury,we mea-sured the levels of ROS,MDA,GSH,Fe2+,and the expression levels of ferroptosis-related proteins(GPX4,FTH1,FPN1)in rat myocardium.The results showed that artesunate significantly improved the cardiac function of rats with exercise-induced myocardial injury,reduced the levels of myocardial injury markers(cTnl,CK-MB,LDH),and decreased myocardial cell apoptosis.Additionally,artesunate significantly reduced the levels of ROS and MDA in the myocardium,increased GSH levels,and inhibited oxidative stress.Artesunate also alleviated ferroptosis by re-ducing myocardial Fe2+content and upregulating the expression of GPX4,FTH1,and FPN1 proteins.In conclusion,artesunate exerts significant protective effects on rats with exercise-induced myocardial injury by regulating iron metabolism and inhibiting ferroptosis,indicating its potential application value.
A rtemisia annuaArtesunateExercise-induced myocardial injury(EIMI)Iron metabolismFerroptosis
万方数据
维普
